Sermorelin & Ipamorelin Blend (10mg)

Description

• Description
• Certificate of Analysis
• HPLC
• Mass Spectrometry

Sermorelin & Ipamorelin Blend – Research Peptide

Product Overview

The Sermorelin & Ipamorelin Blend is a unique combination of two synthetic peptides that have each been studied for their potential to stimulate endogenous growth hormone (GH) secretion. When combined, these compounds may act synergistically, enhancing the overall growth hormone response compared to their individual administration.

Both Sermorelin and Ipamorelin have been of great interest to researchers investigating growth hormone regulation, muscle and bone development, metabolic processes, and age-related hormone modulation.

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What is Sermorelin?

Sermorelin, also known as GRF (1-29) amide, is a synthetic analog of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). While natural GHRH consists of 44 amino acids, Sermorelin comprises only the first 29 amino acids — the essential sequence responsible for biological activity.

Sermorelin is thought to bind to GHRH receptors in the pituitary gland, stimulating the physiological release of growth hormone in a pulsatile pattern. This mimics the body’s natural GH secretion rhythm rather than overriding it. This mechanism of action may lead to a more controlled and physiologically aligned release of growth hormone.

Research suggests Sermorelin can:

• Promote the secretion of endogenous growth hormone

• Stimulate downstream production of insulin-like growth factor 1 (IGF-1)

• Support protein synthesis and cell regeneration in preclinical models

• Maintain pituitary sensitivity due to intermittent GH stimulation rather than constant exposure

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What is Ipamorelin?

Ipamorelin is a highly selective growth hormone secretagogue (GHS) that acts on ghrelin receptors (GHS-R1a) located in the anterior pituitary. Unlike older GHS compounds, Ipamorelin demonstrates remarkable selectivity for the growth hormone axis without significant interaction with other endocrine hormones such as ACTH or prolactin.

Ipamorelin is composed of five amino acids and mimics the natural hunger hormone ghrelin, which is known to promote GH release and influence metabolic processes. Because of its selectivity and mild side effect profile, Ipamorelin is often viewed as one of the most refined GHRPs studied to date.

Research has indicated that Ipamorelin may:

• Increase growth hormone secretion via ghrelin receptor stimulation

• Promote muscle tissue growth and cellular repair

• Support bone density and mineralization

• Enhance metabolic function and energy regulation

• Exhibit a longer biological half-life (~2 hours) compared to Sermorelin (~12 minutes)

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Synergistic Mechanism

When combined, Sermorelin and Ipamorelin may produce complementary effects due to their distinct but convergent pathways of action.

• Sermorelin activates GHRH receptors, stimulating the natural release of GH directly from the pituitary gland.

• Ipamorelin binds to ghrelin receptors, further promoting GH secretion while potentially amplifying and prolonging the release initiated by Sermorelin.

This dual-pathway interaction may result in a more sustained and pronounced growth hormone response, offering an extended window of GH activity in laboratory settings.

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Pharmacokinetic Profile

• Sermorelin Half-Life: 11–12 minutes

• Ipamorelin Half-Life: Approximately 2 hours

Due to these differences, Sermorelin may provide an initial GH pulse, while Ipamorelin may extend the duration of GH elevation, leading to more stable hormonal peaks in controlled research environments.

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Chemical Information

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Research Findings

1. Growth Hormone Secretion

• Studies on Sermorelin have demonstrated an 82–107% increase in GH levels and up to a 28% rise in IGF-1 concentrations following prolonged exposure.

• Ipamorelin, in human and animal studies, has been shown to elevate GH levels by up to 6000% over baseline within hours of administration.

These findings suggest that both peptides strongly influence GH secretion, with potential for sustained activity when used together.

2. Lean Mass and Body Composition

• Sermorelin research indicates potential increases in lean body mass (up to 1.26 kg) without significant changes in fat mass.

• Ipamorelin studies suggest possible improvements in body composition, with increases in both lean tissue and appetite regulation.

• The combined effect may provide a balanced anabolic profile, supporting muscle and tissue development in experimental models.

3. Bone Mineral Density

• Ipamorelin has shown potential to enhance bone mineral content, as observed in DEXA and pQCT scans of animal subjects.

• These effects may relate to increased mechanical loading and hormonal signaling associated with GH and IGF-1.

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Scientific References

1. Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998.

2. Clark RG, Robinson IC. Growth induced by pulsatile infusion of an amidated fragment of human GHRH in normal and GHRH-deficient rats. Nature. 1985.

3. Vittone J, Blackman MR, et al. Effects of nightly injections of GHRH (1-29) in healthy elderly men. Metabolism. 1997.

4. Khorram O, Laughlin GA, Yen SS. Endocrine and metabolic effects of GHRH administration. J Clin Endocrinol Metab. 1997.

5. Svensson J, Lall S, et al. GH secretagogues ipamorelin and GHRP-6 increase bone mineral content in adult female rats. J Endocrinol. 2000.

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⚠️ Disclaimer

This Sermorelin & Ipamorelin Blend is intended for research and laboratory use only. It is not approved for human consumption, medical, or veterinary applications. All product handling should be performed by qualified personnel following appropriate laboratory safety procedures.

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Storage and Stability

• Store lyophilized peptide at -20°C, protected from light and moisture.

• Once reconstituted, store at 2–8°C and use within a limited period.

• Avoid repeated freeze-thaw cycles.

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Specifications

• Size: 5mg vial

• Form: Lyophilized powder

• Purity: >99% (HPLC verified)

• Contents: Sermorelin & Ipamorelin Blend

• SKU: SER-IPA

• Shipping: FREE on orders over $200 (Cloud Pharmacy exclusive)